The play made it to Broadway in 1926 and ran for 172 performances. Gaertner attended the Chicago opening. Its adaptations include:

Performers who have portrayed Roxie Hart in the musical also include Brooke Shields, Ruthie Henshall, Melora Hardin, Ashlee Simpson, Melanie Griffith, Samantha Harris, and Michelle Williams. Simpson and Shields have portrayed the character both on Broadway and The West End. Bebe Neuwirth who won a Tony Award for the role of Velma Kelly in 1997, also portrayed Roxie in the same production in 2006.

Performers who have portrayed Roxie Hart in the musical also include Brooke Shields, Ruthie Henshall, Melora Hardin, Ashlee Simpson, Melanie Griffith, Samantha Harris, and Michelle Williams. Simpson and Shields have portrayed the character both on Broadway and The West End. Bebe Neuwirth who won a Tony Award for the role of Velma Kelly in 1997, also portrayed Roxie in the same production in 2006.